Impact of Different Antihypertensive Drugs on Brachial-Ankle Pulse Wave Conduction Velocity of Essential Hypertension Patients

Objective: To evaluate the changes of brachial-ankle pulse wave conduction velocity after treatment with different antihypertensive drugs in essential hypertension patients.Methods: A total of 120 patients of essential hypertension were equally and randomly divided into three groups according to the antihypertensive drugs of telmisartan(ARB group),amlodipine(CCB group),and perindopril(ACEI group) respectively.Heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP),and brachial-ankle pulse wave conduction velocity(baPWV) were measured after 1 month and 3 months respectively.Results: The SBP,DBP,PP,HR,and baPWV of the three groups had no significant difference before the treatment(P 0.05).After treatment for one month and three months respectively,the SBP,DBP,PP,and baPWV were significantly decreased as compared with pretreatment(all P 0.01).After treatment,the changes of baPWV(△baPWV) were different among the three groups,as ARB group CCB group ACEI group(P 0.05).Conclusion: All the three kinds of drugs of perindopril,amlodipine,and telmisartan can improve arterial elasticity of hypertension patients, and telmisartan has the best effect.