The Influence of Levobupirvacaine Combined with Fentanyl or Tramadol for Patient-controlled Epidural Analgesia

Objective: To compare the clinical effect of levobupivacaine alone or combined with fentanyl or tramadol for patient-controlled epidural analgesia(PCEA) after operation. Methods: 60 parturients undergoing continuous epidural anesthesia after lower extremity operations were equally and randomly divided into three groups. They all received 0.15% levobupivacaine, but group B plus fentanyl (4 μg/mL), and group C plus tramadol (4.0 mg/mL). The PCEA parameters of loading dose 4 mL, single 3 mL, locking the time in 50 minutes and continuous infusion with 1.5 mL/ hour were setup. Results: The total drug dosage, number of button pressed and VAS in geoup A were significantly higher than those in the other groups (P 0.01), which were lowest in group B(P 0.01), the incidence of nausea and vomiting was highest in group C. The incidence of urinary retention among 3 groups was not differnce. The statistic study in RR and MAP were not significant differnce between 3 group(P﹥0.05). Conclusion :The combined with fentanyl epidural analgesia with effect of levobupivacaine is safety and credibility.