Clinical effect of low dose dopamine combined with furosemide early in the treatment of patients with heart failure

Objective To observe the clinical efficacy of early low dose of dopamine combined with furosemide in treatment of patients with heart failure.Methods A total of 124 patients with Newyork Heart Association(NYHA) class III or class IV were enrolled and were randomized into two groups(both,n=62):combining dopamine group,were given low dose of dopamine(0.5~1.0 μg·kg-1·min-1) combined with intravenous furosemide(20~40 mg·d-1);furosemide group,received furosemide(20~40 mg·d-1).The days of hospitalization,diuretic resistance,deterioration of renal function,death,potassium and sodium of serum,blood pressure,heart rate,weight loss,left ventricular ejection fraction(LVEF) values,B-type natriuretic peptide(BNP) composition were observed.Results Days of hospitalization were(5.75±1.30),(8.12±1.10) days(P=0.025) in the dopamine group and furosemide group,respectively.Weight loss,BNP decreased and LVEF rised in conbination group significantly compared with the furosemide group(all P0.05).Total effecte rate was 95.2%,77.42% in conbination group and furosemide group,respectively(P0.05).One patient died only in the furosemide group.Conclusion Early low dose dopamine combined with furosemide usagee in patients with heart failure is more effective than single use of furosemide.