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2014•The Practical Journal of CancerRequires access

Expression of IL-17F and IL-17A in Colorectal Cancer

Xiong Weimi

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Abstract

Objective To explore the relationship between the occurrence and development of colorectal cancer and IL-17F and IL-17A. Methods The expression of IL-17F and IL-17A in 72 patients with colorectal cancer were detected by immunohistochemistry,and the IL-17 F and IL-17A levels were analyzed in different pathological factors. Results The expression of IL-17F and IL-17A in cancer tissues were significantly higher than that of para-neoplastic tissues( P 0. 05). Multiple factors regression analysis showed that the expression of IL-17F and IL-17A was associated with lymph node metastasis,differentiation and TNM stage( P 0. 05). Conclusion The positive expression rates of IL-17F and IL-17A in cancer tissues in patients with colorectal cancer are high,and they are associated with lymph node metastasis,differentiation and TNM stage.

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What this paper is about

Objective To explore the relationship between the occurrence and development of colorectal cancer and IL-17F and IL-17A. Methods The expression of IL-17F and IL-17A in 72 patients with colorectal cancer were detected by immunohistochemistry,and the IL-17 F and IL-17A levels were analyzed in different pathological factors. Results The expression of IL-17F and IL-17A in cancer tissues were significantly higher than that of para-neoplastic tissues( P 0. 05). Multiple factors regression analysis showed that the expression of IL-17F and IL-17A was associated with lymph node metastasis,differentiation and TNM stage( P 0. 05). Conclusion The positive expression rates of IL-17F and IL-17A in cancer tissues in patients with colorectal cancer are high,and they are associated with lymph node metastasis,differentiation and TNM stage.

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Available abstract

Objective To explore the relationship between the occurrence and development of colorectal cancer and IL-17F and IL-17A. Methods The expression of IL-17F and IL-17A in 72 patients with colorectal cancer were detected by immunohistochemistry,and the IL-17 F and IL-17A levels were analyzed in different pathological factors. Results The expression of IL-17F and IL-17A in cancer tissues were significantly higher than that of para-neoplastic tissues( P 0. 05). Multiple factors regression analysis showed that the expression of IL-17F and IL-17A was associated with lymph node metastasis,differentiation and TNM stage( P 0. 05). Conclusion The positive expression rates of IL-17F and IL-17A in cancer tissues in patients with colorectal cancer are high,and they are associated with lymph node metastasis,differentiation and TNM stage.

Key concepts: Colorectal cancer, Pathological, Immunohistochemistry, Interleukin 17, Stage (stratigraphy), Lymph node metastasis, Medicine, Metastasis

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