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Inhibition effect of As_2O_3 and ATRA on human hepatocellular carcinoma HepG2 cell in vitro

Lin Dan

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Abstract

Objective To investigate the difference of As 2O 3 and ATRA alone,as well as their combination in inhibiting HepG2 cells.Methods The antiproliferation activities of As 2O 3 and ATRA on HepG2 were evalua ted by means of MTT assay.The morphological changes of HepG2 were observed by inverted microscope.Results The combination of As 2O 3 and ATRA had an enhanced antiproliferative activity against HepG2.Furthermore, the combination of As 2O 3 and ATRA induced a higher level of apoptosis in HepG2 cell line and inhibition ratio showed positive relationship of concentration time dependence.Conclusion Inorganic arsenical As 2O 3 with ATRA significantly exhibits a synergistic effect on apoptosis induction without major side effects and crossing resistant and increases sensitivity for each other.

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What this paper is about

Objective To investigate the difference of As 2O 3 and ATRA alone,as well as their combination in inhibiting HepG2 cells.Methods The antiproliferation activities of As 2O 3 and ATRA on HepG2 were evalua ted by means of MTT assay.The morphological changes of HepG2 were observed by inverted microscope.Results The combination of As 2O 3 and ATRA had an enhanced antiproliferative activity against HepG2.Furthermore, the combination of As 2O 3 and ATRA induced a higher level of apoptosis in HepG2 cell line and inhibition ratio showed positive relationship of concentration time dependence.Conclusion Inorganic arsenical As 2O 3 with ATRA significantly exhibits a synergistic effect on apoptosis induction without major side effects and crossing resistant and increases sensitivity for each other.

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Available abstract

Objective To investigate the difference of As 2O 3 and ATRA alone,as well as their combination in inhibiting HepG2 cells.Methods The antiproliferation activities of As 2O 3 and ATRA on HepG2 were evalua ted by means of MTT assay.The morphological changes of HepG2 were observed by inverted microscope.Results The combination of As 2O 3 and ATRA had an enhanced antiproliferative activity against HepG2.Furthermore, the combination of As 2O 3 and ATRA induced a higher level of apoptosis in HepG2 cell line and inhibition ratio showed positive relationship of concentration time dependence.Conclusion Inorganic arsenical As 2O 3 with ATRA significantly exhibits a synergistic effect on apoptosis induction without major side effects and crossing resistant and increases sensitivity for each other.

Key concepts: Apoptosis, Hepatocellular carcinoma, In vitro, Chemistry, MTT assay, Molecular biology, Cell culture, Cancer research

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Inhibition effect of As_2O_3 and ATRA on human hepatocellular carcinoma HepG2 cell in vitro — Research Paper | ScholarLens