2011•Zhongguo quanke yixueRequires access
A Clinical Study of Graves Disease Complicated with Leukopenia
Feng Sun
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Abstract
Objective To look into the clinical features as well as treatment approaches and effects of Graves disease complicated with leukopenia.Methods A total of 36 cases of Graves disease complicated with leukopenia diagnosis and treated by our facility were reviewed.Causes of leucopenia,correlations between serum TRAb levels and numbers of leukocytes,and effects of anti-leukopenia therapies were summarized.Results Leukopenia developed after antithyroid treatment(thiamazole:61.9%;propylthiouracil:38.1%) in 21(58.3%) cases,and were caused by in the other 15(41.7%) of the patients.Leukopenia caused by hyperthyroidism were negatively correlated with Serum TRAb levels(P0.01),whereas leucopenia caused by antithyroid drugs showed no correlation with TRAb levels.A medication of leucogen combined with either propylthiouracil or prednisone was applied to the hyperthyroidism cases,while leukopenia caused by anti-thyroid drugs received treatment of leucogen and/or in combination with prednisone,with withdraw of ATD Leukocyte numbers in all cases became normal after treatment.Conclusion Leukopenia in patients with Graves disease may develop from either the intrinsic hyperthyroidism or the side-effects of anti-thyroid drugs.Accordingly,different approaches of treatment should be applied to normalize enumeration of leukocyte.