The effect of recombinant tissue plasminogen combined with urokinaseon in treatment of acute cerebral infarction

Objective To investigate the effect and safety of recombinant tissue plasminogen(rt PA) combined with urokinaseon in treatment of acute cerebral infarction. Methods 129 patients who received thrombolytic therapy in our hospital from November 2005 to December 2012 were selected,and were divided into rt PA group(63 cases) and rt PA combined with urokinaseon group(66 cases).The demographic data,onset-to-needle time and baseline clinical characteristics(symptoms,medical history,blood pressure,blood glucose,blood lipids,National Institutes of Health Stroke Scale(NIHSS) score,Barthel index(BI) were recorded at baseline.The NIHSS and BI were recorded at 7 days,30 days and 90 days after thrombolysis.The mortality rate and theincidences of intracerebral and other hemorrhages were recorded. Results After intravenous thrombolysis each follow-up time point,NIHSS and BI of two groups was improved than that before treatment,the difference was significant(P0.05);Follow-up for 90 days,the improvement of NIHSS in rt PA group was better than that of rt PA combined with urokinase group,but there was no significant difference(P0.05).There was no significant difference on the safety and efficacy between the two groups(P0.05). Conclusion For patients with acute cerebral infarction and no contraindications onset within 6 hours,the efficacy and safety of rt PA combined with urokinase is similar to urokinase thrombolytic.