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Preliminary study on antifungal activity of new derivative of sulfone against Fusarium oxysporum

Baoan Song

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Abstract

The antifungal activity of 2-(benzylsulfonyl)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole(2008334)against Fusarium oxysporum was preliminary evaluated with the method of mycelial growth rate in vitro.The results showed that the EC50 value of compound-2008334 was 27.54 μg/mL,which was similar with that of hymexazol(29.13 μg/mL).The spore germination of F.oxysporum can be inhibited by compound-2008334 with EC50 value as 41.37 μg/mL.After treated by 2008334 at 100 μg/mL,the permeability of the cell membrane increased significantly,and the contents of reducing sugar and soluble protein in mycelia increased for a short time,and decreased subsequently.

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What this paper is about

The antifungal activity of 2-(benzylsulfonyl)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole(2008334)against Fusarium oxysporum was preliminary evaluated with the method of mycelial growth rate in vitro.The results showed that the EC50 value of compound-2008334 was 27.54 μg/mL,which was similar with that of hymexazol(29.13 μg/mL).The spore germination of F.oxysporum can be inhibited by compound-2008334 with EC50 value as 41.37 μg/mL.After treated by 2008334 at 100 μg/mL,the permeability of the cell membrane increased significantly,and the contents of reducing sugar and soluble protein in mycelia increased for a short time,and decreased subsequently.

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Available abstract

The antifungal activity of 2-(benzylsulfonyl)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole(2008334)against Fusarium oxysporum was preliminary evaluated with the method of mycelial growth rate in vitro.The results showed that the EC50 value of compound-2008334 was 27.54 μg/mL,which was similar with that of hymexazol(29.13 μg/mL).The spore germination of F.oxysporum can be inhibited by compound-2008334 with EC50 value as 41.37 μg/mL.After treated by 2008334 at 100 μg/mL,the permeability of the cell membrane increased significantly,and the contents of reducing sugar and soluble protein in mycelia increased for a short time,and decreased subsequently.

Key concepts: Fusarium oxysporum, Mycelium, Spore germination, EC50, Chemistry, Antifungal, In vitro, Fusarium

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