Expression and significance of MMP-2,MMP-9 and VEGF in endometriosis

Objective: To investigate the expression and significance of EMMPRIN,MMP-2 and MMP-9 in endometriosis(EMs).Methods: The expression of MMP-2,MMP-9 and EMMPRIN in 42 cases of ectopic endometrium,42 cases of eutopic endometrial and 20 cases of normal endometrium were detected by two-step immunohistochemical method,then the correlation of the expression of them was evaluated.Results: The MMP-2,MMP-9 and EMMPRIN positive expression rate was 95.24%、92.86% and 90.48% respectively in the ectopic endometrium group,which were significantly higher than their counterparts in the eutopic endometrial group and the normal endometrium group(P0.05);there was not significant difference between the eutopic endometrial group and the normal endometrium group.The expression of EMMPRIN protein was positively correlated with MMP-2,9 in the ectopic endometrium group(P0.01).Conclusion: EMMPRIN,MMP-2 and MMP-9 are all involved in the process of invasionand tissue remodeling,which is supposed to be part of pathogenesis of endometriosis and EMMPRIN protein plays its role probably through activating MMP-2,9 synthesis and secretion.