2006•Journal of Zhengzhou UniversityRequires access

Detection of matrix metalloproteinase-9 and MVD in astrocytoma tissue

Songwei Yue

Abstract

Aim: To investigate the expression of matrix metalloproteinase-9 in astrocytomas and its correlation with neoplastic angiogenesis. Methods:The expression of MMP-9 and the change of microvessel density (MVD) were detected in 40 cases of astrocytomas by immunohistochemical staining.Results: MVD and expression of MMP-9 in astrocytoma at Ⅰ～Ⅱ grade was 34.73±12.56 and 48.13±9.74,and in Ⅲ～Ⅳ grade was 63.96±18.29 and 65.34±7.76. MVD and expression of MMP-9 in astrocytoma at Ⅰ～Ⅱ grade was significantly lower than those in Ⅲ～Ⅳ grade astrocytoma( P0.01). There was correlation between MVD and expression of MMP-9 in human astrocytomas. Conclusion: MVD and expression of MMP-9 are positively correlated with the grade of astrocytoma. MMP-9 plays an important role in the angiogenesis of astrocytoma.

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Key concepts: Astrocytoma, Immunohistochemistry, Matrix metalloproteinase, Angiogenesis, Pathology, Matrix metalloproteinase 9, Medicine, Glioma