Research of relative factors between bronchiolitis and asthma by long time follow-up of 180 children bronchiolitis patients

OBJECTIVE 180 children bronchiolitis patients with the hospitalization treatment were followed up long time,then the relative factors between bronchiolitis and asthma were analyzed.METHODS The data of 180 children bronchiolitis patients with the hospitalization treatment were retrospectively analyzed.All the children were followed up for five years.Sex,family history,immunoglobulin,feeding patterns,inhaled corticosteroid,allergic constitution and passive smoking were observed.Logistic regression analysis was used to analyze the relationship between the factors and asthma.RESULTS 35 of 180 patients(19.4%)with bronchiolitis converted to asthma.Univariate analysis results showed that there were significant difference of family history,immunoglobulin,feeding patterns,inhaled corticosteroid,allergic constitution and passive smoking between the children with or without asthma(P﹤0.05).Logistic regression analysis showed that family history,allergic constitution and passive smoking were the risk factors for asthma,and breast feeding,immunoglobulin and inhaled corticosteroid were the protective factors.CONCLUSION Family history,allergic constitution and passive smoking were the risk factors for asthma.Breast feeding,immunoglobulin and inhaled corticosteroid treatment will decrease the occurrence of asthma.