The Rencent Progress of the Mitochondrial Permeability Transition Pore and Cell Apoptosis

To today,the structure of mitochondrial permeability transition pore( PT) is a puzzle. Recently the mitochondrial phosphate carrier which belongs to a part of mitochondrial carriers′ family,is supposed to be the main component part of PT. While the cyclophilin,adeninenucleotide translocase and voltage-depend- ent anion channel are modulators of the opening of the mitochondrial permeability transition pore. PT is closely associated with the cell apoptosis. But there are no inevitable relationship between them. So to discuss the relationships among the mitochondrial permeability transition pore,the mitochondrial phosphate carrier and cell apoptosis.