Study on Relationship between Insulin Resistance and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

Objective To investigate the relationship between insulin resistance and non-alcoholic fatty liver disease(NAFLD)in patients with type 2 diabetes mellitus(T2DM).Methods The levels of fasting plasma glucoes(FPG),fasting insulin(FInS),triglycerides(TG),total cholesterol(TC),high density lipoprotein(HDL) and low density lipoprotein(LDL) were detected,the insulin resistance index(HOMA – IR) was calculated in 54 diagnosed patients with T2DM and NAFLD,and compared with 38 diagnosed patients with T2DM without NAFLD.Results The levels of plasma FPG,FInS,HOMA – IR,TG,TC,LDL in patients with T2DM and NAFLD were significantly higher than the control group(P0.05 or P0.01).Conclusion There are significant insulin resistance and lipid metabolic disorder in patients with T2DM and NAFLD.It is necessary to take measures to control the patient's blood sugar,reduce insulin resistance and improve lipid metabolism for the prevention and treatment of DAFLD in T2DM.