Effect of sulfentanyl on cellular immune function and hormonal level in patient with esophagus cancer during operation

OBJECTIVE To compare the effect of sulfentanyl on cellular immune function and hormonal level in patients with esophagus cancer during operation.METHODS 96 patients with esophagus cancer,who received resection of carcinoma of esophagus in January 2010-December 2011 in our hospital,were randomly divided into observation group and control group.The patients in observation group and control group separately received combined anesthesia of sulfentanyl and fentanyl.T cells(CD4+ and CD8+) and hormone(grow hormone,prolactin and cortisol) were determined before anesthesia(T0),at the moment of skin cut(T1),thoracotomy(T2),tracheal extubation(T3),24 h after operation(T4) and 48 h after operation(T5).RESULTS ① Level of CD4+,CD8+ and CD4+/CD8+in both groups was not significantly different at T0(P0.05),and was significantly decreased at T1,T2,T3,T4 and T5 compared with that at T0(P0.01).Level of CD4+,CD8+ and CD4+/CD8+ in observation group was significantly higher than that in control group at T1,T2,T3,T4 and T5,but level of CD8+in both groups did not significantly changed after operation(P0.05).② Level of grow hormone,prolactin and cortisol in both groups were not significantly different at T0(P0.05),and was significantly decreased at T1,T2,T3,T4 and T5 compared with that at T0(P0.01).CD4+,CD8+ and CD4+/CD8+ in observation group was significantly higher than that in control group at T1,T2,T3,T4 and T5,but level of CD8+in both groups did not significantly changed after operation(P0.05).CONCLUSION Sulfentanyl can reduce the inhibition of cellular immune function,decrease hormonal level during the operation,and can be used in combined anesthesia in patients with esophagus cancer during operation.