Anti-fatigue Effect of Acanthopanax senticosus Processed by Hericium erinaceus

Objective:To explore the anti-fatigue effect of Acanthopanax senticosus fermented by Hericium erinaceus.Method:Fourty mice were divided randomly into 5 groups: low dose group(1.625 g.kg-1),middle dose group(3.25 g.kg-1),high dose group(6.5 g.kg-1),blank control group(0.9% NaCl),positive control group(3.25 g.kg-1).Drug were administered to mice for 30 days.The dosage was 0.02 mL.g-1.The antifatigue effect was evaluated by the swimming time,the blood lactic acid clearance rate,the content of BUN and glycogen.Result: Each index in middle-dose group of A.senticosus fermented by H.erinaceus showed significant difference compared with the Blank and positive control groups respectively.Conclusion: A.senticosus processed by H.erinaceus has stronger antifatigue effects than the A.senticosus raw material.