Relationship between left ventricular end-diastolic pressure of patients with coronary disease and the ratio of mitral velocity to early diastolic velocity of the mitral annulus

Objective To assess the ratio of mitral velocity to early diastolic velocity of the mitral annulus(E/E') with coronary disease associated with left ventricular end-diastolic pressure(LVEDP).Methods Thirty consecutive patients with coronary disease underwent transthoracic Doppler echocardiography within 24 hours before cardiac catheterization.Doppler signals from the mitral inflow,TDI of the mitral annulus were obtained.LVEDP was obtained with pig-tailed catheters.Results Linear regression analysis showed E/E' had the better correlation with LVEDP(S:r=0.739,P0.01;L:r=0.710,P0.01).In septal area,E/E'≥10 predicted LVEDP≥15 mmHg with a sensitivity of 85%,a specificity of 89%,in lateral wall E/E'≥10 predicted LVEDP≥15 mmHg with a sensitivity of 82%,a specificity of 89%.Conclusions E/E' provides valuable parameters for estimating of LVEDP,and may provide a semi-quantitative index for predicting LVEDP(15 mmHg) elevation.