Untoward Effect of Rhubarb Extract on Female Rats PituitaryGonad Axis after the Long-Term Administration

Objective:To observe the role of rhubarb extract on female rats Pituitary-Gonad Axis after the long-term administration.Methods:40 Wistar female rats were divided into four groups,the dose groups were given 20,40,80 times as the normal administration of the medication women.Blank group was given equal volume of distilled water.After feeding 90 d,the blood was obtained from the orbital.The amounts of serum estradiol(E2)and luteinizing hormone(LH)were detected by RIA.Results:The level of serum E2 from high-dose group had significantly increased and positive correlation between dose of rhubarb extract.The level of LH was significantly decreased and negatively correlated with the dose.Conclusion:Taking large doses of rhubarb extract for a long-term can elevate the level of serum E2.Meanwhile the level of LH was decreased.