ScholarLens Back to search
2003•Journal of Brain and Nervous DiseasesRequires access

Up-regulation of hypoxia-inducible factor-1α is a key event in focal cerebral ischemic tolerance in rats

Hao Yu

Open publisher page 0 citations

Abstract

Objective: To investigate the expression of hypoxia-inducible factoi-1α( HIF-1α) in ischemic toIerance induced by focal ischemic preconditioning in rals. Methods:32 rats were divided into 3 groups in which control group received sham sur-gery (SS) only, and the other two groups received 2h middle cerebral artery occlusion ( MCAO) followed by 22h reperfusion with 10min ischemic preconditoning or SS 3d before. Infarct volume and expression of HIF-1α were evalualed in each group Results: Compared with the SS group, there was a smaller infarct volume and stronger HTF-1α immunoreactivity in PC group. Conclusions: 10min MCAO was strong enough to induce ischmic tolerance and increase HIF-1α expression. Up-regulation of HIF-1α might be a key event in [he molecular mechanism of focal cerebral ischemic tolerance.

About this research paper

What this paper is about

Objective: To investigate the expression of hypoxia-inducible factoi-1α( HIF-1α) in ischemic toIerance induced by focal ischemic preconditioning in rals. Methods:32 rats were divided into 3 groups in which control group received sham sur-gery (SS) only, and the other two groups received 2h middle cerebral artery occlusion ( MCAO) followed by 22h reperfusion with 10min ischemic preconditoning or SS 3d before. Infarct volume and expression of HIF-1α were evalualed in each group Results: Compared with the SS group, there was a smaller infarct volume and stronger HTF-1α immunoreactivity in PC group. Conclusions: 10min MCAO was strong enough to induce ischmic tolerance and increase HIF-1α expression. Up-regulation of HIF-1α might be a key event in [he molecular mechanism of focal cerebral ischemic tolerance.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To investigate the expression of hypoxia-inducible factoi-1α( HIF-1α) in ischemic toIerance induced by focal ischemic preconditioning in rals. Methods:32 rats were divided into 3 groups in which control group received sham sur-gery (SS) only, and the other two groups received 2h middle cerebral artery occlusion ( MCAO) followed by 22h reperfusion with 10min ischemic preconditoning or SS 3d before. Infarct volume and expression of HIF-1α were evalualed in each group Results: Compared with the SS group, there was a smaller infarct volume and stronger HTF-1α immunoreactivity in PC group. Conclusions: 10min MCAO was strong enough to induce ischmic tolerance and increase HIF-1α expression. Up-regulation of HIF-1α might be a key event in [he molecular mechanism of focal cerebral ischemic tolerance.

Key concepts: Ischemia, Hypoxia (environmental), Ischemic preconditioning, Anesthesia, Medicine, Cardiology, Internal medicine, Chemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Up-regulation of hypoxia-inducible factor-1α is a key event in focal cerebral ischemic tolerance in rats — Research Paper | ScholarLens