The Progression of microRNA and Tumor's Research

MicroRNA(miRNA) is a kind of small non-protein-coding RNA about 22 nucleotides in length.MicroRNA can regulate organism growth and development by mediating the degradation of complementary mRNA or inhibiting translation.MicroRNA play important roles in homeostatic processes such as development,cel1 proliferation,cell apoptosis.It was certified that miRNA participate the processes of tumorigenesis and development and its expression profiles can be used as the indicator of tumor diagnosis and prognosis.Mutation,deletion or high expression of miRNA was found to correlate with various human cancer.miRNA is involved in tumor cell proliferation,differentiation and apoptosis processes as function as oncogenes or tumor supressors.In this review,we have summarized the research of miRNA in tumorigenesis,development,diagnosis and therapy.