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PUMA: a new target in cytoprotective and tumor therapy

Aimin Meng

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Abstract

PUMA (p53 upregulated modulator of apoptosis) is a member of the Bcl-2 family and plays a powerful pro-apoptotic role. The studies showed that the decrease of PUMA expression was closely related to the occurrence of tumor and upregulation of PUMA expression could enhance tumor sensitivity to radiotherapy and chemotherapy. The deletion of PUMA could effectively reduce the damage of radiotherapy and chemotherapy to normal tissues. Here we review the research progress of PUMA as a therapeutic target in cancer treatment and cytoprotection.

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What this paper is about

PUMA (p53 upregulated modulator of apoptosis) is a member of the Bcl-2 family and plays a powerful pro-apoptotic role. The studies showed that the decrease of PUMA expression was closely related to the occurrence of tumor and upregulation of PUMA expression could enhance tumor sensitivity to radiotherapy and chemotherapy. The deletion of PUMA could effectively reduce the damage of radiotherapy and chemotherapy to normal tissues. Here we review the research progress of PUMA as a therapeutic target in cancer treatment and cytoprotection.

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Available abstract

PUMA (p53 upregulated modulator of apoptosis) is a member of the Bcl-2 family and plays a powerful pro-apoptotic role. The studies showed that the decrease of PUMA expression was closely related to the occurrence of tumor and upregulation of PUMA expression could enhance tumor sensitivity to radiotherapy and chemotherapy. The deletion of PUMA could effectively reduce the damage of radiotherapy and chemotherapy to normal tissues. Here we review the research progress of PUMA as a therapeutic target in cancer treatment and cytoprotection.

Key concepts: Puma, Downregulation and upregulation, Radiation therapy, Apoptosis, Cancer research, Cytoprotection, Chemotherapy, Medicine

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