2008•Shandong yiyaoRequires access

Expression of VEGF and its effect on relationship to angiogenesis in adenomyosis

Aiqing Zhang

Abstract

Objective To investigate the expression of VEGF in adenomyosis and its effect on angiogenesis.Methods Expression of VEGF protein and MVD in 34 ectopic lesions and eutopic endometrium in adenomyosis(study group) as well as 30 normal endometrium(control group) were detected by immunohistochemistry.RT-PCR was used to measure the expression of VEGF mRNA in adenomyosis.Results The expression rate of VEGF in the eutopic and ectopic endometrium of proliferate and secretary phase in adenomyosis was higher than that of the control group,the rate of ectopic endometrium was higher than that of eutopic endometrium.The rate of eutopic endometrium of the secretary phase was higher than that of proliferate phase in two groups.The MVD of the ectopic and eutopic endometrium in adenomyosis was higher than that of the control group.There was a positive correlation between VEGF and MVD.Conclusions The expression lever of VEGF,VEGF mRNA and MVD in the ectopic endometrium of adenomyosis was high,and their expression had a positive correlation.

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Key concepts: Adenomyosis, Angiogenesis, Immunohistochemistry, Endometrium, Medicine, VEGF receptors, Vascular endothelial growth factor, Endometriosis