Antitumor activity of Shenmai Injection

Objective To investigate the antitumor effect of Shenmai Injection in vitro and in vivo.Methods Solid tumor models of mouse sarcoma S 180,hepatoma H 22,and Lewis lung carcinoma were used to study the antitumor effect of Shenmai Injection in vivo.MTT assay was used to examine its inhibitory effect on the proliferation of HeLa cell and HepG 2 cells.Results Shenmai Injection showed obviously inhibitory effect on the growth of S 180,H22,and Lewis in tumor-bearing mice in a dose-dependent manner,and inhibitory rates in mid-and high-dose groups were over 35%.Shenmai Injection also inhibited the proliferation of HeLa cells and HepG 2 cells in vitro,showing a concentration-time correlation.The IC 50 values of 48 h were 0.36 and 0.72g/mL and the IC 50 values of 72h were 0.21 and 0.29g/mL.Conclusion Shenmai Injection has remarkable antitumor activity both in vitro and in vivo.