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2010•Jiangsu Medical JournalRequires access

Efficacy of FLAG regimen in treatment of refractory acute leukemia in children

Zhao Wen-l

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Abstract

Objective To summarize the efficacy of FLAG regimen\[cytarabine(Ara-C)+fludarabine(Flud)+granulocyte colony-stimulating factor(G-CSF)\] in treatment of refractory acute leukemia(AL) in children.Methods Five cases,aged 5 to 13 years old,with refractory AL were treated by FLAG regimen:Flud 30 mg·m-2·d-1,d 2-6,Ara-C 2 g·m-2·d-1,d 2-6,G-CSF 5 μg·kg-1·d-1,d 1-6.Results Of 5 cases,2 cases obtained complete remission(CR),3 case had no myeloremission.Myelosuppression was main adverse reaction.Conclusion The FLAG regimen has good results in treating refractory AL in children with tolerable side effects.

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Objective To summarize the efficacy of FLAG regimen\[cytarabine(Ara-C)+fludarabine(Flud)+granulocyte colony-stimulating factor(G-CSF)\] in treatment of refractory acute leukemia(AL) in children.Methods Five cases,aged 5 to 13 years old,with refractory AL were treated by FLAG regimen:Flud 30 mg·m-2·d-1,d 2-6,Ara-C 2 g·m-2·d-1,d 2-6,G-CSF 5 μg·kg-1·d-1,d 1-6.Results Of 5 cases,2 cases obtained complete remission(CR),3 case had no myeloremission.Myelosuppression was main adverse reaction.Conclusion The FLAG regimen has good results in treating refractory AL in children with tolerable side effects.

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Available abstract

Objective To summarize the efficacy of FLAG regimen\[cytarabine(Ara-C)+fludarabine(Flud)+granulocyte colony-stimulating factor(G-CSF)\] in treatment of refractory acute leukemia(AL) in children.Methods Five cases,aged 5 to 13 years old,with refractory AL were treated by FLAG regimen:Flud 30 mg·m-2·d-1,d 2-6,Ara-C 2 g·m-2·d-1,d 2-6,G-CSF 5 μg·kg-1·d-1,d 1-6.Results Of 5 cases,2 cases obtained complete remission(CR),3 case had no myeloremission.Myelosuppression was main adverse reaction.Conclusion The FLAG regimen has good results in treating refractory AL in children with tolerable side effects.

Key concepts: Flag (linear algebra), Refractory (planetary science), Regimen, Medicine, Fludarabine, Cytarabine, Gastroenterology, Internal medicine

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