Neuroprotective effect of edaravone on cerebral trauma rats

Objective To investigate the neuroprotective effect of edaravone,a kind of free radical scavenger on cerebral trauma rats.Methods To separate SD rats into group experimental(n=32) and group control(n=32).Knock-on device was used to create cerebral trauma model.Both groups were administered with edaravone by caudal vein 30 minutes before and 3 hours after knocking.To execute the two groups of rats after injured 6 hours,24 hours,3 days and 7 days,detected cerebral cell apoptosis by TUNEL,and analyzing 8-hydroxy-deoxyguanosine levels by immunohistochemistry.Results Edaravone seemed to put no significant influence on physiological index of rats during the early period of injury(P 0.05).But it obviously reduced neurologic function score of group experimental compared to group control(P 0.05).Meanwhile,the neuron apoptosis of group experimental significantly decreased as well.Edaravone markedly suppressed the 8-hydroxy-deoxyguanosine in injury tissue(P 0.05).Conclusion Edaravone exerted neuroprotective effect on cerebral trauma rats.And the mechanism is possibly related to scavenging the free radicals and reducing brain edema.