2010•Heilongjiang yiyao kexueRequires access
Of Irbesartan on early diabetic nephropathy podocyte molecules nephrin,podocin mRNA expression inEffects of irbesartan on expression of rat podocyte nephrin and podocin in early diabetic nephropathy
Changhong Li
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Abstract
Objective:To investigate the effects of irbesartan on expression of podocyte nephrin and podocin mRNA in early diabetic nephropathy rats.Methods :Thirty-six Wistar rats were divided into three groups: normal group,diabetic nephropathy group and irbesartan intervention group.The Irbesartan intervention group was given irbesartan 50mg·kg-1·d-1 for gavage and the normal control group and diabetic nephropathy group were given equal amount of drinking water for gavage,The 24h urinary protein.Results:At 8 and 12 weeks after the models were prepared,there was a difference in the levels of 24h urinary protein and serum creatinine between the diabetic nephropathy group and normal group(P0.01),and in the 24 h urinary protein level between the Irbesartan intervention group and the diabetic nephropathy group(P0.05) and in the serum creatinine level between the Irbesartan intervention group and the diabetic nephropathy group at 12 weeks(P0.05).There was a difference in the nephrin and podocin mRNA expression levels at 8 and 12 weeks between the diabetic nephropathy group and the normal group(P0.01) and between the Irbesartan intervention group and the diabetic nephropathy group(P0.05).Conclusion:Irbesartan can improve the podocyte function and reduce proteinuria in diabetic nephropathy by up regulation of the expression of nephrin and podocin