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Preliminary Studies on DNA Repair Capacity in Peripheral Primitive Lymphocytes of the Patients with Acute Lymphatic Leukemia

A Hangzhou

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Abstract

The level of ultraviolet-induced 3~H-TdR unscheduled incorporation in the peripheral blood primitive lymphocytes obtained from 11 patients with acute lymphatic leukemia are observed in matched test. The results reveal that unscheduled DNA synthesis (UDS) level in the acute lymphatic leukemia group is significantly lower than normal control group. The actual CPM values(± SD)are 115±13 versus 257±13(P0.01), UI_1 are 0.50±0.05 versus 1.09±0.04 (PO.01), UI_2 are 1.53±0.02 versus 2.11±0.02 (P0.01). It is suggested that the DNA-excision repair defect exists in the patients with acute lymphatic leukemia

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What this paper is about

The level of ultraviolet-induced 3~H-TdR unscheduled incorporation in the peripheral blood primitive lymphocytes obtained from 11 patients with acute lymphatic leukemia are observed in matched test. The results reveal that unscheduled DNA synthesis (UDS) level in the acute lymphatic leukemia group is significantly lower than normal control group. The actual CPM values(± SD)are 115±13 versus 257±13(P0.01), UI_1 are 0.50±0.05 versus 1.09±0.04 (PO.01), UI_2 are 1.53±0.02 versus 2.11±0.02 (P0.01). It is suggested that the DNA-excision repair defect exists in the patients with acute lymphatic leukemia

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Available abstract

The level of ultraviolet-induced 3~H-TdR unscheduled incorporation in the peripheral blood primitive lymphocytes obtained from 11 patients with acute lymphatic leukemia are observed in matched test. The results reveal that unscheduled DNA synthesis (UDS) level in the acute lymphatic leukemia group is significantly lower than normal control group. The actual CPM values(± SD)are 115±13 versus 257±13(P0.01), UI_1 are 0.50±0.05 versus 1.09±0.04 (PO.01), UI_2 are 1.53±0.02 versus 2.11±0.02 (P0.01). It is suggested that the DNA-excision repair defect exists in the patients with acute lymphatic leukemia

Key concepts: Acute leukemia, Lymphatic leukemia, Lymphatic system, Leukemia, Chronic lymphatic leukemia, Peripheral blood, DNA, Medicine

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Preliminary Studies on DNA Repair Capacity in Peripheral Primitive Lymphocytes of the Patients with Acute Lymphatic Leukemia — Research Paper | ScholarLens