Investigation of Relevant Influential Factors of HBeAg Quantitation with Telbivudine Treatment on Chronic Hepatitis B Patients

OBJECTIVE To investigate the influential factors of HBeAg quantitation with telbivudine treatment on HBeAg-positive patients with chronic hepatitis B.METHODS Totally 124 HBeAg-positive patients with chronic hepatitis B were therapied with telbivudine for 48 weeks.Observed the change of ALT levels,HBV DNA load and HBeAg quantitation before and after the treatment,and analyzed the influences of baseline HBV DNA load before treatment,ALT levels,and different phases of HBV DNA undetectable during the treatment to HBeAg quantitation with telbivudine treatment on HBeAg-positive patients for 48 weeks.RESULTS The number of HBV DNA undetectable was 103(83.1%),the number of ALT normalization was 122(98.4%),the number of HBeAg undetectable was 45(36.2%),and the number of HBeAg seroconversion was 32(25.8%) after treatment for 48 weeks.Baseline HBV DNA load before treatment and ALT levels had influence on HBeAg quantitation and the rate of HBeAg undetectable.The rate of HBeAg undetectable was 47.3% in HBV DNA107 Coples·mL-1 group and 27.5% in HBV DNA≥107 Coples·mL-1 group after treated with telbivudine for 48 weeks;the rate of HBeAg undetectable was 58.5% and 19.7% in ALT≥200 U·L-1 group and ALT200 U·L-1 group after treated with telbivudine for 48 weeks.Different phases of HBV DNA undetectable during treatment had significant influence on degrading HBeAg quantitation and the rate of HBeAg undetectable after treated with telbivudine for 48 weeks.The rate of HBeAg undetectable was 53.8% in the group which the time of HBeAg undetectable was less than 12 weeks,the rate of HBeAg undetectable was 37.1% in the group which the time of HBeAg undetectable between 12 and 24 weeks,and the rate of HBeAg undetectable was 25% in the group which the time of HBeAg undetectable was more than 24 weeks.CONCLUSION Baseline HBV DNA load before treatment,ALT levels,and different phases of HBV DNA undetectable have significant influences on HBeAg quantitation after treatment with telbivudine for 48 weeks.