2006•Zhonghua neifenmi daixie zazhiRequires access

Melatonin decreases expression of transforming growth factor-β_1 in renal cortex of diabetic rats

Xiaowen Tu

Abstract

Transforming growth factor-β_1 (TGF-β_) mRNA or protein expression in renal cortex of diabetic rats was assessed by real-time quantitative RT-PCR with SYBR Green,immunohistochemistry or Western blot.After melatonin treatment,the expressions of TGF-β_1 mRNA and protein were decreased,suggesting that beneficial effect of melatonin may result from its antioxidative property and inhibiting TGF-β_1 expressions.

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Available abstract

Key concepts: Melatonin, Endocrinology, Internal medicine, Transforming growth factor, Renal cortex, Messenger RNA, Western blot, Immunohistochemistry