Change of plasma P selectin levels in patients with metabolic syndrome and combined with coronary artery disease

Objective:To detect the change of the plasma P selectin levels in metabolic syndrome(MS) patients and in MS combined with coronary artery disease(CAD)patients,then to explore the relationship between P-selectin and insulin sensitivity index(ISI),and the role of P-selectin in development from MS to CAD.Methods:A total of 80 MS patients were divided into two groups according to the diagnostic criteria of MS and CAD and 40 healthy subjects were randomly selected(normal control group).Results:The plasma p-selectin levels increased one by one in normal control group,MS group,MS+CAD group[(25.1±3.6)ng/ml:(33.1±5.1)ng/ml:(41.3±8.4)ng/ml,P0.05].The ISI in normal control group were much higher than that of other two groups [(-1.5±0.1) vs.(-1.8±0.2)vs.(-1.8±8.4),P0.05].The Pearson relation analysis showed that the plasma p-selectin levels were negatively correlated with ISI(r=-0.460,P0.05).Conclusion:P-selectin may play an important role in the develop from metabolic syndrome to coronary artery disease,and have potential clinical significance.