2006•Chinese Journal of MisdiagnosticsRequires access
The Changes of Serum IL-6 and TGFβ_1 Levels in Diabetic Nephropathy Patients and the Therapeutic Effects of Rosuvastatin on Patients with Diabetic Nephropathy
Xiaofang Li
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Abstract
Objective:To investigate the clinical significance of serum IL-6 and TGFβ_1 in patients with diabetic nephropathy,and the therapeutic mechanism of rosuvastatin.Methods:The sera levels of IL-6 and TGFβ_1 were determined by ELISA in healthy controls,diabetic patients without nephropathy,patients with diabetic nephropathy and patients with diabetic nephropathy treated with rosuvastatin.The sera levels of IL-6 were measured with radioimmunoassay and the sera levels of and urine protein of 24h were determined with salicylic acid nephelometry.Results:(1)The sera levels of IL-6 and TGFβ_1 were increased progressively in the order of healthy controls,diabetic patients without nephropathy and patients with diabetic nephropathy.The serum levels IL-6 and TGFβ_1 were increased significantly in patients with diabetic nephropathy compared with those in controls(P0.05),although there was no significant difference in the urine protein contents of 24 h between two groups(P0.05).The urine protein contents of 24,the levels of IL-6 and TGFβ_1 in patients with diabetic nephropathy were significantly higher than those in control group(P0.01),and also significantly higher than those in diabetic patients without nephropathy(P0.05).(2)After treatment with rosuvastatin for 8 weeks in patients with diabetic nephropathy,the urine protein contents of 24h,the serum levels of IL-6 and TGFβ_1 were all decreased significantly compared with those before treatment respectively(P0.05).After treatment for 15 weeks the above indices remained decreased until treatment for 28 weeks(P0.01).Conclusion:(1)IL-6 and TGFβ_1 play a very important role in the progenesis of diabetic nephropathy.(2)the therapeutic mechanism of rosuvastatin in patients with diabetic nephropathy lies probably in the inhibition of IL-6 and sTGFβ_1 expression,thus directly or indirectly affecting the proliferation of mesangial cells and mesangial matrix.