2014•Chinese Journal of General PracticeRequires access
Clinical value of combined detection of serum TK1,CA125 in diagnosis of ovarian cancer
Jin Wang
Open publisher page 0 citations
Abstract
Objective To explore the significance of detection serum thymidine kinase 1( TK1),carbohydrate antigen 125( CA125) in diagnosis of ovarian cancer. Methods The levels of serum TK1 were detected by enhanced chemiluminiscence dot-blot assay in 82 patients with ovarian cancer( ovarian cancer group),46 patients with benign ovarian disease( benign disease group) and 35 health people( control group). The levels of serum CA125 were detected by chemiluminescence immunoassay. Results The levels of serum TK1,CA125 in patients with ovarian cancer were significantly higher than those in patients with benign ovarian disease and control group( P 0. 01). The sensitivity,specificity and accuracy of combined detection of the two markers were significantly higher than those of single detection( P 0. 05). Conclusion Serum TK1 and CA125 might have important value in diagnosis of ovarian cancer. Combined detection of the two markers could significantly improve the diagnostic value of ovarian cancer.