Late Complications and Efficacy of Conventional Radiotherapy and Intensity-modulated Radiotherapy for Nasopharyngeal Carcinoma

Objective To compare the late complications and efficacy of conventional radiotherapy and intensity-modulated radiotherapy for nasopharyngeal carcinoma. Methods 160 cases of nasopharyngeal carcinoma were divided into the conventional radiotherapy group and the intensity-modulated radiotherapy group. The late complications and treatment results were analyzed retrospectively. Results There were significant difference in xerostomia,the incidence of neck fibrosis and radiation encephalopathy between the 2 groups( P 0. 05); There was no significant difference in limited mouth opening,the incidence of dental caries,and hearing loss( P 0. 05); There was no significant difference in 1 ~ 3 year overall survival rate between the 2groups( P 0. 05); There were significant differences in 4-year overall survival rate and 7-year overall survival rate between the 2groups( P 0. 05),and the IMRT group was higher than the conventional radiotherapy group. Conclusion Conclusion IMRT for nasopharyngeal carcinoma has fewer late complications,higher long-term survival and better long-term efficacy.