Effects of Xuemaijian on Blood Lipid and Vessel Morphology in rabbits with Atherosclerosis

Objective To study the effects of Xuemaijian(XMJ) on blood lipid and vessel morphology in rabbits with atherosclerosis.Methods As control group(CG),10 rabbits were randomly chosen from 50 healthy Japanese white rabbits,and the remaining 40 rabbits were induced to atherosclerosis model by Immunostimulatory and Feeding high fat diet for 2 months.According to blood lipid level,atherosclersis rabbits were randomly divided into model group(MG,10),atorvastatin group(AG,10) and Xuemaijian group(XG,10).Except CG and MG taking boiled water,rabbits in AG were aderministrated in atorvaststin Suspension(0.45 mg/kg?d) and rabbits in XG in Xuemaijian liquid(0.40 g/kg?d) for one month.Serum total cholesterol(TC)、 Triglyceride(TG)、high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C) levels were determinated,pathological changes of the aortic were observed and the plaque thickness and area were calculated.Results The aortic intima was smooth,no plaque and lipid points,three clear structure of the vascular wall in Control group.The intima was rough,uneven,white plaques of varying sizes,lipid plaque with a large number of foam cell accumulation and infiltration of inflammatory cells in model group.Atorvastatin group and Xuemaijian group were markedly attenuated than model group,plaque area and plaque thickness was significantly lower than the model group(P 0.01).Compared with the control group,the TC,HDL-C,LDL-C levels in model group were significantly increased than atorvastatin group and tXuemaijian group(P 0.01).Compared with model group,TC,HDL-C,LDL-C of atorvastatin group and Xuemaijian significantly decreased(P 0.01).Conclusion Xuemaijian plays a obvious role in adjusting blood lipid and improving atherosclerotic plaque on experimental atherosclerosis rabbits,its mechanism needs further study.