Clinical Manifestations of Neurological Involvement in Primary Sj觟gren's Syndrome

Objective: To evaluate the incidence rates of neurological disorders in pSS patients,and investigate the clinical manifestations of peripheral and central nervous complications in pSS.Methods: 34 patients with pSS were enrolled in the present study.The clinical features were evaluated by neurological physical examination,magnetic resonance imaging,cerebrospinal fluid,and nerve electro-physiological examination.Results: 15 of 34 pSS were with neurological involvement,11 of whom manifested as peripheral nervous involvement: 3 were cranial neuropathy,6 were polyneuropathy,1 was mononeuritis multiplex,1 was suspected having SFN;4 of whom manifested as central nervous involvement: 1 patients with head and spinal cord demyelination,2 cases of brain single focal lesions,1 patient with brain stem lesions.There was no statistical difference between the pSS patents with and without neurological involvement.Conclusion: The frequency of pSS with neurological complication was 44.1%.Peripheral neuropathies were more common especially sensory neuropathies,but there was no specific nervous system changes.Compared to the patients without nervous system lesions,the laboratory results which prompted the diagnosis had no significant difference in the patients with nervous system lesions.