Organic injury and changes of cytokines in paraquat poisoning patients

Objective To observe the organic injury and changes of cytokines in acute paraquat poisoning patients.Methods 10 ml venous blood was drawn from 15 paraquat poisoning patients 48 h later after taking poisoning for liver and renal function determination and cytokines detection. Arterial blood gas and lung HRCT were also been done at the same time. Fifteen volunteers were invited as control. The determination of liver and renal function,arterial blood gas according to routine methods and the detection of cytokines according to the instruction of kits by enzyme linked immunosorbent assay.Results Paraquat could induce respiratory system, digestive system and urinary system manifestation. The serum alanine aminotransferase,aspartate aminotransferase,total bilirubin,blood urea nitrogen,creatiine were increased by paraquat(P0.05 or P0.01). PO_2, PCO_2, pH,BE,HCO~-_3 were decreased by paraquat(P0.01). Cytokines PDGF,IGF-1,TNF-α,IL-10 were increased by paraquat. Conclusion Paraquat could induce lung, kidney and liver injury and cytokines may play an important role on the pathogenesis of paraquat poisoning.