Study on preparation and in vitro drug release of actarit solid lipid nanoparticles

OBJECTIVE To prepare Actarit solid lipid nanoparticles(A-SLN)and to study the in vitro drug release behavior.METHODS Based on the result of single-factor experiments,4 factors were selected to search the best formulation and the best preparation routes with orthogonal experiments.The diameters and the zeta potential were measured.TEM was used to observe the particles shapes.And study the in vitro drug release rate.RESULTS The drug entrapment efficiency(EE%) was detected.The mean particle size was found to be 120 nm with a narrow particle distribution of polydispersity index,(0.233).The zeta potential of the A-SLN which was produced by the best formulation was(17.14) mV and the drug entrapment efficiency was(51.20%). The in vitro drug release rate profile could be described by equation 100Q=(38.536)t~(1/4)-(16.859)(r=(0.999 0))(0～12 h) and 100Q=(13.907)t~(1/4)+(28.32)(r=(0.999 2))(13～648 h).CONCLUSION A-SLN with sustained release property could be achieved by solvent emuldification / evaporation method.