The Effect of Ulinastatin on the Plasma IL-6 of the Patients in Cardiopulmonary Bypass

Objective To investigate whether Ulinastin can reduce the heart muscle ischemia reperfusion injury induced by cardiopulmonary bypass. Methods Forty patients scheduled for cardiac surgery were randomly allocated into two groups,Ulinastatin group(group U,n=20) and control group(group C,n=20).Group U in which patients received a total of 12000 u/ kg of ulinastatin.6000 u/ kg ulinastatin was given a IV bolus on introduction of anesthesia and before CPB.Group C in which patients received an equal amount of isotonic sodium chloride solution.Blood samples were taken from radial artery before introduction of anesthesia(T0),10 min after initiation of CPB(T1),30 min after initiation of CPB(T2),1 h(T3),3 h(T4) and 6 h(T5) after CPB for determination of plasma IL6 concentrations.Alveolar-arterial oxygen A-aDO2 were checked at T0,T3,T4,T5.Results There was no significant difference between two groups in age, weight,operation time,CPB time,and aortic cross-clamping time.Compared with those at T0,the concentrations increased significantly at T1-T5 in two groups(P0.05).There was no difference between two groups at T0.The concentrations of IL-6 at T1-T5,A-aDO2 at T3-T5 in group U was lower than those in group C significantly (P0.05).Conclusion Ulinastatin suppressed the excessive release of IL-6 and protected lung injury in patients undergoing cardiopulmonary bypass.