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2009•Chinese Journal of PharmaceuticalsRequires access

Determination of Residual Organic Solvents in Pantoprazole Sodium by Capillary GC

Song Wei-guo

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Abstract

A static headspace capillary GC method was established for simultaneous determination of six residual organic solvents in pantoprazole sodium. A DM-1 capillary column was used with DMF-H2O(8∶2) as the solvent and FID was used as detector. The calibration curves of six solvents were linear in the concentration ranges of 24 -1 200,40 -2 000,40 -2 000,5 -240,40 -2 000,and 7 -356 μg/ml,respectively. The average recoveries were 98.6% -100.3% with RSDs of 1.3% -2.1%. Their detection limits were 0.3,0.27,0.19,0.19,0.16,0.8 μg/ml,respectively.

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What this paper is about

A static headspace capillary GC method was established for simultaneous determination of six residual organic solvents in pantoprazole sodium. A DM-1 capillary column was used with DMF-H2O(8∶2) as the solvent and FID was used as detector. The calibration curves of six solvents were linear in the concentration ranges of 24 -1 200,40 -2 000,40 -2 000,5 -240,40 -2 000,and 7 -356 μg/ml,respectively. The average recoveries were 98.6% -100.3% with RSDs of 1.3% -2.1%. Their detection limits were 0.3,0.27,0.19,0.19,0.16,0.8 μg/ml,respectively.

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Available abstract

A static headspace capillary GC method was established for simultaneous determination of six residual organic solvents in pantoprazole sodium. A DM-1 capillary column was used with DMF-H2O(8∶2) as the solvent and FID was used as detector. The calibration curves of six solvents were linear in the concentration ranges of 24 -1 200,40 -2 000,40 -2 000,5 -240,40 -2 000,and 7 -356 μg/ml,respectively. The average recoveries were 98.6% -100.3% with RSDs of 1.3% -2.1%. Their detection limits were 0.3,0.27,0.19,0.19,0.16,0.8 μg/ml,respectively.

Key concepts: Chemistry, Chromatography, Calibration curve, Detection limit, Residual, Solvent, Capillary action, Pantoprazole

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