The clinical study of staphylococcal protein A immunoadsorption in the treatment of generalized myasthenia gravis

Objective To study the efficacy and safety of staphylococcal protein A immunoadsorption in the treatment of generalized myasthenia gravis.Methods Nineteen cases of definitely diagnosed generalized MG were treated with protein A immunoadsorption.Clinical and safety assessments were evaluated at baseline and after the first and second immunoadsorption.Results At the end of treatment,Osserman grade,MGFA,ADL and MMT were improved significantly(P0.0001).Accordingly,serum IgG,IgA and IgM concentrations were decreased significantly(P0.0001).Individuals with positive AChR antibody were found to have a lower titer after treatment.The percentage of peripheral regulatory T cells was increased after treatment.Some patients had mild side effect,but the general tolerance was good.All the safety parameters showed no significant difference between baseline and post-treatment.Conclusions With possible mild side effect,staphylococcal protein A immunoadsorption could improve the symptoms of generalized myasthenia gravis quickly.