Detection of angiotensin I converting enzyme gene insertion/deletion polymorphism in patients with myocardial infarction

Aim:To explore the polymorphism of angiotensin I converting enzyme gene insertion/deletion in the patients with myocardial infarction(MI). Method:Ninety-three patients with MI and eighty-seven healthy controls were tested. ACE genomic DNA was amplified using polymerase chain reaction(PCR). Risk factors with MI were assessed. Result:There was no significant difference among genotype in terms of age, sex, body mass index(BMI), blood pressure, cholesterol, triglyceride, and glucose. The frequency of ACE DD genotype and D alleles(32.3% and 54.3% ) in MI group was significantly higher than that of control group(12.6% and 37.4%) ( P 0.01, respectively). In MI group, the DD genotype frequency in multivessel disease patients were higher than that in single disease patients, but had no statistical significance ( P 0.05). Conclusion:The polymorphism of ACE DD genotype is associated with increased risk for myocardial infarction, but has no correlation with classic MI risk factors.