Study on Protective Effects of Lycopene on Acudte Alcohol Liver Injury in Mice

Objective:To study the protective effects of lycopene against the acute alcohol liver injury in mice and research its possible mechanism for offering scientific basis of its health function.Methods:Randomly distribute 60 male Kunming mices to control group,acute alcohol liver injury model group,DDB group(15mg/kg) and low,middle,high dose groups of lycopene(10,15,20mg/kg).Determinaiton and comparing of liver index between groups,assay serum alanine transaminase(ALT),aspartate transaminase(AST),superoxide dismutase(SOD),glutathione perioxidase(GSH-Px) activities,malondialdehyde(MDA) content,liver SOD,GSH-Px activities,MDA content and liver tissue pathology index.Results:Treatment with different dose lycopene could signficantly increase serum and liver tissue SOD,GSH-Px activities(P0.01),decrease serum ALT,AST levels(P0.01) and MDA content in liver tissue(P0.01).Pathology index observations showed that lycopene could ameliorate the liver injury in different degree.Conclusion:Lycopene shoed protective effects on the acute alcohol liver injury induce by alcohol in mice.