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The Change of Transmural Heterogeneity of Ventricular Repolarization in Rabbit Dilated Cardiomyopathy Models

J. Zhong

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Abstract

We used Adriamycin to create rabbit models of DCM, and evaluated theirs ventricular fibrillation threshold (VFT), transmural dispersion of repolarization (TDR) and action potential duration at 90% repolarization (APD) in epicardium, midmyocardium and endocardium. In rabbit models of DCM, VFT apparently decreased (P0.001) and TDR increased (P0.01). The APD90 prolonged in three myocardial layers, but prolongation of APD90 in midmyocardial cells was much more significant than in the epicardial and endocardial cells. So we got the conclusion that the increase of transmural heterogeneity of ventricular repolarization was an important reason, which caused ventricular fibrillation in rabbit models of DCM.

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What this paper is about

We used Adriamycin to create rabbit models of DCM, and evaluated theirs ventricular fibrillation threshold (VFT), transmural dispersion of repolarization (TDR) and action potential duration at 90% repolarization (APD) in epicardium, midmyocardium and endocardium. In rabbit models of DCM, VFT apparently decreased (P0.001) and TDR increased (P0.01). The APD90 prolonged in three myocardial layers, but prolongation of APD90 in midmyocardial cells was much more significant than in the epicardial and endocardial cells. So we got the conclusion that the increase of transmural heterogeneity of ventricular repolarization was an important reason, which caused ventricular fibrillation in rabbit models of DCM.

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Available abstract

We used Adriamycin to create rabbit models of DCM, and evaluated theirs ventricular fibrillation threshold (VFT), transmural dispersion of repolarization (TDR) and action potential duration at 90% repolarization (APD) in epicardium, midmyocardium and endocardium. In rabbit models of DCM, VFT apparently decreased (P0.001) and TDR increased (P0.01). The APD90 prolonged in three myocardial layers, but prolongation of APD90 in midmyocardial cells was much more significant than in the epicardial and endocardial cells. So we got the conclusion that the increase of transmural heterogeneity of ventricular repolarization was an important reason, which caused ventricular fibrillation in rabbit models of DCM.

Key concepts: Repolarization, Medicine, Endocardium, Cardiology, Internal medicine, Ventricular fibrillation, Atrial action potential, Dilated cardiomyopathy

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The Change of Transmural Heterogeneity of Ventricular Repolarization in Rabbit Dilated Cardiomyopathy Models — Research Paper | ScholarLens