2011•PubMedRequires access

[Clinical trial of cellulose in treatment of functional constipation in children].

Junping Lu, Ying Huang, Ye Zhang, Xiaohui Wang, Cai-hong Shao

Abstract

OBJECTIVE: To study the efficacy and safety of cellulose for the treatment of functional constipation in children. METHODS: A prospective, self-controlled, clinical trial using cellulose was conducted for 2 weeks in 34 children with functional constipation. The constipation symptoms and the characteristics of feces after the treatment were observed. RESULTS: The characteristics of feces and the constipation symptoms were improved significantly after the treatment. The total efficacy rate was 37% 3 days after treatment, 87% 7 days after treatment and 90% 14 days after treatment. The satisfactory rates of doctors and children's parents on the therapeutic effects were 57% and 63%, respectively. No adverse events, such as abdominal distention, pain or diarrhea, were observed during the treatment. CONCLUSIONS: Cellulose is effective and safe in the treatment of functional constipation in children.

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Key concepts: Constipation, Functional constipation, Medicine, Diarrhea, Abdominal pain, Defecation, Feces, Clinical trial