Effects of perindopril on ET-1,AngIIand hs-CRP in renal hypertensive rats

Objective To research the effect of perindopril on the endothelial function in two kidney and one clip (2K1C) hypertensive rats.Methods Forty-five adult male Wistar-Kyoto rats were ramdoly divided into 3 groups;sham-opera tion group(n = 15),2K1C renal hypertension rat(RHR) group(n = 15),2K1C + perindopril group(2.4 mg ? kg~(-1) ? d~(-1),n=15 ).The SBP were measured by tail cuff method at the time points of pre and post operation,and calculate the ratio of heart and body weight.At the same time by nitric acid reduction method for determination of serum nitric oxide(NO) level. Enzyme linked immunosorbent assay method for the determination of serum endothelin-1(ET-1 ) level.Blood plasma Angll was measured with radioimmunoassay.Turbidimetric immunoassay method for the determination of high sensitive C reactive protein(hs-CRP).Results Compared with sham-operation group,SBP level at different time-points increased significantly in model group(P0.01 ),compared with model group,perindopril group decreased SBP significandy(P0.01),NO were found to be significantly decreased in the 2K1C hypertensive rats compared with those of the sham-operation group(P0.05),Perindopril treatment increased NO(P0.05).At the same time,the Angll and ET-1 levels were reduced in different degree(P0.01);Effect of perindopril on 2K1C hypertensive rats hs-CRP level significantly reduced(P0.05, P0.01).Conclusion The effect of perindopril on blood pressure control was validated,as well improve the function of vascular endothelium in hypertensive rats.