Clinical study on serum leptin levels and endocrine hormones in gestational diabetes mellitus.

Objective To investigate the relationship between serum leptin levels and endocrine hormones in patients who experienced gestational diabetes mellitus(GDM),and its effect on fetal growth.Methods Serum leptin,E2,PROG,HPL,C-Peptide and insulin levels were determined by RIA.The leptin,insulin and Cpeptide levels of newborn umbilical cord blood were determined by RIA as well.Results(1)Leptin levels in patients with GDM were significantly higher than GIGT and normal pregnancy group(P0.01);Serum leptin levels of newborn were significantly lower than GIGT and normal pregnancy group(P0.01).(2)E2 levels of normal pregnancy group,GIGT and GDM were higher than non-pregnant group(P0.01).(3)Serum leptin levels of normal pregnency group and GDM group correlated with PROG(P0.01,P0.05);Serum leptin levels of GDM and GIGT correlated with asphyxia neonatorum(P0.01,P0.05).Conclusion(1)There is mutual regulation of leptin and endorcrine hormones during preg-nancy;(2)The increasing of serum leptin levels participates in the development of GDM,so the leptin can be taken as one of indexes during perinatal monitor for GDM.