2007•Medical Journal of National Defending Forces in Northwest ChinaRequires access
Studies on the expression of utrophin in muscles of the patients with childhood muscular dystrophy
PU Chuan-qian
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Abstract
Objective: To investigate the expression of utrophin and dystrophin in muscles of the patients with childhood muscular dystrophy(MD).Methods: The expression of utrophin wes analyzed by immunofluorescence methods with the muscle biopsies from 8 patients with childhood MD and 2 normal controls.Results: Immunofluorescence reactivity for utrophin was weak and discontinuous in a minority sarcolemma of Duchenne muscular dystrophy(DMD) patients with severely reduced dystrophin.Utrophin was negative on sarcolemma of DMD patients with moderate decreased dystrophin and other non-DMD muscular dystrophies.There was no immunofluorescence reactivity for utrophin on sarcolemma of normal biopsies.Conclusion: The expression of utrophin in childhood MD was related to the decline of dystrophin expression,and may has relationship with the severity of clinical symptom.