Analysis on the common pathogen distribution and drug resistance of urinary tract infection

Objective Reseach on the distribution of common pathogens and their resistance of the clinical urinary tract infection to guide clinical use of antimicrobial agents.Methods 795 pathogens were isolated from the urine culture of the out-patients and hospitalized patients with urinary tract infection from Jan.2006 to Nov.2008,and the pathogens were identified and put into vitro drug resistance testing,and Escherichia coli,Klebsiella pneumoniae was under the defection of super-extended-spectrum β-lactamase(ESBL).Results Totally,795 pathogens were isolated from the specimens of the patients with urinary tract infection,with 398 strains of gram negative bacilli,counted for 50.1%,230 strains ofGram positive bacteria(28.9%),167 strains of fungi counted for 21.0%.The main pathogens were escherichia coli 254(31.9%),167 fungus(21.0%),enterococcus faecalis 77(9.7%),enterococcus faecium 74(9.3%),klebsiella pneumoniae and 41 of the pseudomonas aeruginosa(5.2%).ESBL confirmatory test: Of 254 escherichia coli,152 were deteced out,with the enzyme production rate of 59.8%;Of 41 Klebsiella pneumoniae,32 were detected out,with the enzyme production rate of 78.1%.Pathogen isolation rate and the upward trend of drug resistance were increasing.Conclusion Escherichia coli,enterococci,fungus are the main pathogens of urinary tract infection,and drug resistance isolated from the clinic is in a very serious situation.Therefor,the proper use of antimicrobial agents should be strengthened,and attention should be paied to dynamic monitoring of bacterial resistance in guiding clinical rational use of antimicrobial drugs.It is of great importance in controling control the spread of drug resistance strains,and proventing the occurrence of infection in the hospital.