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Clinical significance of urine MCP-1 determination in patients with lupus nephritis

Shi Yong-ju

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Abstract

Objective To explore the clinical significance of urine monocyte chemoattractant protein-1 (MCP-1) in patients with lupus nephritis (LN). Methods Urine MCP-1 was detected by Enzyme-linked immunosorbent assay (ELISA). Correlation analysis of urine MCP-1 and renal injury, urine MCP-1 and the activity indices of renal histopathologic change were evaluated. Results Urine MCP-1 level in LN patients (1130±403) pg/mg Cr was significantly higher than that of normal controls (141±109) pg/(mgCr) (P0.01) and primary nephritis patients (452±174) pg/mg Cr (P0.01). Urine MCP-I was significantly correlated with proteinuria (r=0.558, P0.05), serum creatinine level (r=0.869, P0.01), urine NAG (r=0.617, P0.05) and the activity indices (AI) of renal histopathologic change (r=0.751, P0.01). Conclusion Urine MCP-1 can be used as a molecular maker to evaluate disease activity of patients with lupus nephritis.

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Objective To explore the clinical significance of urine monocyte chemoattractant protein-1 (MCP-1) in patients with lupus nephritis (LN). Methods Urine MCP-1 was detected by Enzyme-linked immunosorbent assay (ELISA). Correlation analysis of urine MCP-1 and renal injury, urine MCP-1 and the activity indices of renal histopathologic change were evaluated. Results Urine MCP-1 level in LN patients (1130±403) pg/mg Cr was significantly higher than that of normal controls (141±109) pg/(mgCr) (P0.01) and primary nephritis patients (452±174) pg/mg Cr (P0.01). Urine MCP-I was significantly correlated with proteinuria (r=0.558, P0.05), serum creatinine level (r=0.869, P0.01), urine NAG (r=0.617, P0.05) and the activity indices (AI) of renal histopathologic change (r=0.751, P0.01). Conclusion Urine MCP-1 can be used as a molecular maker to evaluate disease activity of patients with lupus nephritis.

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Available abstract

Objective To explore the clinical significance of urine monocyte chemoattractant protein-1 (MCP-1) in patients with lupus nephritis (LN). Methods Urine MCP-1 was detected by Enzyme-linked immunosorbent assay (ELISA). Correlation analysis of urine MCP-1 and renal injury, urine MCP-1 and the activity indices of renal histopathologic change were evaluated. Results Urine MCP-1 level in LN patients (1130±403) pg/mg Cr was significantly higher than that of normal controls (141±109) pg/(mgCr) (P0.01) and primary nephritis patients (452±174) pg/mg Cr (P0.01). Urine MCP-I was significantly correlated with proteinuria (r=0.558, P0.05), serum creatinine level (r=0.869, P0.01), urine NAG (r=0.617, P0.05) and the activity indices (AI) of renal histopathologic change (r=0.751, P0.01). Conclusion Urine MCP-1 can be used as a molecular maker to evaluate disease activity of patients with lupus nephritis.

Key concepts: Urine, Lupus nephritis, Medicine, Proteinuria, Nephritis, Internal medicine, Creatinine, Clinical significance

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