The cardiovascular stress reaction to tracheal intubation under different anesthesia induction in pediatric patients

Objective Random-controlled perspective study was performed to compare cardiovascular stress reaction to tracheal intubation in pediatric patients and evaluate the inhibitory effect of different anesthesia induction on the cardiovascular stress reaction during tracheal intubation.Methods According to the anesthesia type,58 children of 1 to 6 years old were randomly divided into 3 groups,group P(5mg/kg of thiopental injected intravenously by a bolus),group PF(given 3 μg/kg of fentanyl injection intravenously,followed by 5 mg/kg of thiopental intravenous injection)and group PFI(given 3 μg/kg of fentanyl injection intravenously,followed by 5 mg/kg of thiopental intravenous injection and 3% isoflurane inhalation).All tracheal intubation was operated by the same clinician.Blood pressure(BP)and heart rate(HR)before anesthesia,before and after intubation were recorded.Results HR and BP after intubation were the highest in group P,significantly higher than that before intubation and basic value(P0.05).HR and BP after intubation in group PF were higher than that before intubation,but lower than that in group P,not different from basic value.HR and BP after intubation in group PFI were the lowest in 3 groups with a lowest ascending amplitude(that of systolic blood pressure and diastolic blood pressure was 10% and 24% respectively),a little higher than that before intubation,but significantly lower than basic value.Conclusion It suggests that thiopental,fentanyl and isoflurane should be administrated simultaneously to reduce cardiovascular reaction and inhibit the stress reaction caused by tracheal intubation.