A study on relationship between the myocardial mitochondrial DNA deletion in the cases of dilated cardiomyopathy and sudden death

Objective:To study the myocardial mitochondrial DNA (mt DNA) deletion in the cases of sudden death due to dilated cardiomyopathy and its relationship with sudden death. Method:To extract myocardial mtDNA from the cases of sudden death due to dilated cardiomyopathy and the control group autopsied in our department with common method and to detect laser density of the production with PCR ultraviolet ray imaging technique, and then the rate of myocardial mtDNA 4977 deletion were tested quantitatively. Result:In 11 cases of sudden death due to dilated cardiomyopathy, the mtDNA 4977 deletion had been detected in all cases(100%). In 14 cases of control group, the mtDNA 4977 deletion had been detected in only 2 cases ( 14.28%).The average value of myocardial mtDNA 4977 deletion rate in two groups were 0.92% and 0.09% respectively and their difference had statistically significance. Conclusion: Myocardial mtDNA 4977 deletion can be detected in all cases of sudden death due to dilated cardiomyopathy and the mutation of myocardial mtDNA 4977 deletion is related to sudden death.